منابع مشابه
Hypercapnia and acidosis in sepsis: a double-edged sword?
Acute respiratory distress syndrome is a devastating disease that causes substantial morbidity and mortality. Mechanical ventilation can worsen lung injury, whereas ventilatory strategies that reduce lung stretch, resulting in a "permissive" hypercapnic acidosis (HCA), improve outcome. HCA directly reduces nonsepsis-induced lung injury in preclinical models and, therefore, has therapeutic poten...
متن کاملRoles of hypercapnia and acidosis in the vasodilator response to hypercapnic acidosis.
KONTOS, HERMES A., DAVID W. RICHARDSON, AND JOHN L. PATTERSON, JR. Roles of hypercapniu and acidosis in the vasodilutor response to hyperc@c acidosis. Am. J. Physiol. 2 15 (6) : 1406-1408. 1968.-The importance of increased Pcoz and decreased pH in the mediation of the effects of hypercapnic acidosis on heart rate, blood pressure, and blood flow and vascular resistance of the human forearm were ...
متن کاملSepsis and therapeutic hypercapnia: sailing too close to the wind?
ALMOST a decade ago, the landmark study of low tidal volume ventilation (6 vs. 12 ml/kg ideal body weight) in the acute respiratory distress syndrome (ARDS) showed that a strategy leading in some cases to carbon dioxide retention (permissive hypercapnia) reduced mortality by a remarkable 25%. Lung protective ventilation is now the standard of care for acute lung injury and ARDS. Lack of obvious...
متن کاملAn audit of hypoxaemia, hyperoxaemia, hypercapnia and acidosis in blood gas specimens.
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متن کاملEffects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction.
Acute respiratory disorders and permissive hypercapnic strategy may lead to alveolar hypoxia and hypercapnic acidosis. However, the effects of hypercapnia with or without acidosis on hypoxic pulmonary vasoconstriction (HPV) and oxygen diffusion capacity of the lung are controversial. We investigated the effects of hypercapnic acidosis and hypercapnia with normal pH (pH corrected with sodium bic...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2010
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3181ca361f